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In Vitro Fertilization - IVF- Success Rates
The main factors affecting IVF outcome include the following : -
- age of the woman ( and consequently, her ovarian reserve )
- normalcy of the uterus, and semen quality
- success or failure of fertilization and cleavage in vitro
- number of embryos transferred and cryopreserved
- adequacy of the luteal phase after transfer
In addition, success rates increase as the number of IVF stimulation attempts increase, probably ranging to a maximum of three to four stimulation cycles.
Success Rates
Average statistics may not apply to an individual patient or couple within an age or treatment group. Success rates vary depending on many factors including the causes of infertility, the adequacy of ovarian reserve ( as measured by cycle day - 3 serum FSH, LH, estradiol levels, and the clomiphene citrate challenge test ), and the number, maturity, and quality of eggs retrieved.
It is important to understand the philosophy with which the Select IVF Surrogacy India partner Fertility centres approaches the management and treatment of infertility. Here, our goal is to help couples achieve their dreams of having children. Select IVF Surrogacy India partner Fertility centres do not pre-select patients; in other words, they do not exclude couples due to the presence of factors that may negatively impact their success rates. For example, one third of the female patients are "low responders ( they are more than 37 years of age and / or have a day - 3 FSH greater than 10 mIU / ml ( normal range is between 3 - 10 mIU / mL for the assay used in our laboratories ).
In addition, another third of our patients performed at least one failed IVF cycle elsewhere. These two factors are typically considered to compromise success; nonetheless, we have been able to achieve pregnancies in many of these cases. As a consequence, Select IVF Surrogacy India partner Fertility centres offers all couples the possibility of enrollment and participation in an IVF attempt to have their own genetic children.
In addition, and up to a certain point, success rates in our program increase as the number of IVF stimulation attempts increases. There are several methods of calculating pregnancy rates. Here, we include our most recent results for IVF and donor egg cycles, our cryopreserved cycle pregnancy rates, and the so - called total reproductive potential success rates. The IVF rates include information on female age because a disproportionately high number of treated young females may result in higher than "normal" success rates. This is an important factor when comparing success rates from different treatment centers as fertility usually begins to decline in females aged mid to late thirties.
IVF
The mean female's age was 34 years (range 28-43 years), the average number of mature eggs retrieved was 11, and 45% of cycles provided embryos for cryopreservation.
The clinical pregnancy rate per transfer was 44%.
The mean number of embryos transferred was 2.18.
Not surprisingly, the pregnancy rates were directly influenced by patient's age: <30 years: 50%; 30 - 34 years: 47%; 35 - 37 years: 48%; 38 - 40 years: 33%; and >40 years: 11%.
Donor eggs
- The average donor's age was 26 years, and the donor egg recipients ranged from 34 to 49 years.
- The clinical pregnancy rate per transfer was > 50%.
- The mean number of embryos transferred was 3.0.
- Endoscopic surgeries prior to IVF treatment are performed in the Select IVF Surrogacy India partner Fertility centres in India. Many women who are not able to conceive due to problems like fibroids.
In Vitro Fertilization ( IVF ), donor eggs, and embryo cryopreservation
In Vitro Fertilization ( IVF ), donor eggs, and embryo cryopreservation
Table 1 - IVF Success Rates 2005 - 2007
( includes ICSI )
Cycle Type |
Pregnancy Rate/Transfer |
| Donor Egg ( n = 65 ) |
51% |
| IVF ( n = 104 ) |
46% |
Cryopreserved / Thawed Embryos
( n = 55 ) |
28% |
Table 2 - IVF Results 2005 - 2007
( all stimulation protocols, includes ICSI )
Female Age |
Pregnancy Rate / Transfer |
Multiple Pregnancy Rate |
# Embryos Transferred |
<35 Years (n = 75) |
41% |
33% |
2.5 |
35 - 39 (n = 42) |
36% |
26% |
2.8 |
>40 (n = 18) |
15% |
15% |
2.9 |
There are two ways to increase the odds of pregnancy. One is to freeze extra pre - embryos, if available, and the other is to try again.
Select IVF Surrogacy India partner Fertility centres, they have long been a leader in freezing embryos ( cryopreservation ). In patients who produce many healthy embryos, freezing these extra embryos can give another chance for pregnancy at a lower cost, thereby increasing cost - efficiency.
The other way to increase long - term chances of achieving a pregnancy is simply to try again. While the chance for success on a second or third try are no higher ( or lower ) than on a first try, simply repeating the effort over time leads to a higher chance overall. Table 3 lists total reproductive potential success rates ( TRP ). The TRP is an important indicator of success. It refers to the number of pregnancies obtained from only one stimulated cycle, as the result of a fresh embryo transfer cycle plus at least one additional cycle of transfer of cryopreserved - thawed embryos derived from that same stimulation. This process greatly reduces the costs for multiple transfer attempts. The Jones Institute consistently produces cryopreserved pregnancy rates among the highest in the world. As shown, IVF patients with good prognosis as well as recipients of donor eggs have a greater than 60% chance of pregnancy expressed as TRP.
Table 3- Total Reproductive Potential, 2000 - 2007
( Luteal Lupron Protocol, all female ages, includes ICSI )
Procedure |
Total Reproductive Potential |
IVF ( n = 110 ) |
58% |
Donor Egg ( n = 65 ) |
71% |
Embryo cryopreservation yields multiple advantages to patients. It is important for physicians and patients to understand and comprehend the total reproductive potential per cycle based on this assessment of overall pregnancy rates. Obviously, programs with poor cryopreserved pregnancy rates, or no cryopreservation program, offer a lower TRP pregnancy rate. We encourage you to discuss this with your physicians.
Male factor infertility is present in up to 40% of infertile couples. Intracytoplasmic sperm injection (ICSI ) has become a "boom" in the treatment of men with sperm anomalies undergoing IVF. Table 5 presents results of ICSI compared to standard IVF during the period of 2000 through 2007. As shown, the utilization of ICSI in men with poor sperm parameters yields similar pregnancy results as those obtained with IVF in men with normal semen analysis.
Table 4 - Success Rates ICSI vs. IVF, 1994 - 2007
( luteal Lupron protocol, age < = 38 years )
|
ICSI |
IVF |
Number of Cycles |
571 |
474 |
Fertilization Rate ( % ) |
70% |
71% |
Pregnancy Rate/Transfer ( % ) |
42% |
44% |
Implantation Rate ( % ) |
21% |
19% |
Hydrosalpinx and IVF Success Rates
During the past few years, evidence has accumulated that the presence of a unilateral or bilateral hydrosalpinx ( obstructed and dilated tube/s ) reduces the success rate after IVF and embryo transfer. The mechanism for this is not clearly understood although there is evidence for embryotoxicity in the tubal fluid and lack of expression of markers of implantation in these patients. There also is evidence that removal ( usually by a laparoscopy on an outpatient basis ) of the affected tube/s improves significantly the pregnancy rate. If you think that you have such affected tubes, please send us your details.
Related Links : Ivf Probability
For more information, medical assessment and medical quote
send your detailed medical history and medical reports
as email attachment to
Email : - info@selectsurrogacyindia.com
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